Explore plain-language guides to MTHFR, COMT, MTR, MTRR, AHCY, VDR and other genes connected with folate processing, methionine recycling, vitamin B12 transport and methyl-group use.
“Methylation genes” is an informal term for genes involved in, or commonly discussed alongside, folate metabolism, one-carbon metabolism, methionine recycling, vitamin B12 handling, methyl-group transfer and related signaling pathways.
They do not act as simple on-or-off switches. A useful report considers multiple variants, the wider pathway, current health information and appropriate clinical biomarkers when relevant.
Search by gene symbol, full gene name, nutrient, or pathway. The categories are simplified for navigation because several genes contribute to more than one biological process.
A commonly reviewed MTHFR variant that may provide inherited context about an enzyme involved in producing a folate form used in one-carbon metabolism.
Read the MTHFR C677T guideAnother commonly reviewed MTHFR variant that is best considered alongside C677T, other folate-related genes and the wider pathway rather than in isolation.
Read the MTHFR A1298C guideSupports the interconversion of folate-related forms used in one-carbon metabolism, nucleotide production and connected cellular processes.
Read the MTHFD1 guideConnects serine and glycine metabolism with folate-dependent one-carbon transfer, adding context beyond MTHFR alone.
Read the SHMT1 guideEncodes an enzyme involved in a vitamin B12-dependent pathway that converts homocysteine toward methionine as part of methionine recycling.
Read the MTR guideHelps maintain the activity of the MTR enzyme and is commonly reviewed with MTR when considering vitamin B12-dependent methionine-cycle steps.
Read the MTRR guideParticipates in a recycling step involving S-adenosylhomocysteine and helps provide context about balance within the wider methionine and methyl-transfer network.
Read the AHCY guideEncodes an enzyme that uses methyl groups when processing catechol compounds, including pathways involving certain neurotransmitters and related molecules.
Read the COMT guideProvides inherited context related to vitamin D signaling and receptor activity. A VDR result does not measure a person’s current vitamin D level.
Read the VDR guideEncodes a vitamin B12-binding protein and may contribute additional inherited context when reviewing B12-related transport and processing pathways.
Read the TCN1 guideEncodes a transport protein involved in delivering vitamin B12 to cells and may add context to B12-dependent pathway interpretation.
Read the TCN2 guideCommonly discussed in relation to inherited secretor status and may provide additional context in reports covering vitamin B12 and gastrointestinal-related pathways.
Read the FUT2 guideTry searching by a gene symbol, full gene name, nutrient, or pathway. You can also clear the filters to view the complete library.
Folate reactions, methionine recycling, vitamin B12 handling and methyl-group use are connected. Looking at one gene alone can leave out important context from the rest of the network.
These genes help provide context about folate-form conversion, movement of one-carbon units and connected nucleotide-related processes.
These genes provide context about vitamin B12 transport, B12-dependent remethylation and recycling steps within the methionine cycle.
These genes add context related to methyl-group use, catechol metabolism and vitamin D receptor signaling rather than measuring neurotransmitter or vitamin levels directly.
Genetic variants are common. Their significance depends on the exact variant, evidence quality, related genes and the wider personal and clinical context.
Review the broader explanation in our Understanding Methylation guide .
Many variants are common within the population. A reported variant should not automatically be treated as a defect, disease, or explanation for symptoms.
Methylation-related processes involve multiple genes, nutrients, enzymes, tissues and regulatory steps that interact with one another.
A gene result cannot confirm a present folate, vitamin B12, vitamin D, homocysteine, iron, zinc, hormone, or neurotransmitter level.
Do not stop medication, start high-dose supplements, or make major medical decisions based only on a wellness genetic report.
A person’s inherited variants do not change between California, Texas, New York, Florida, or any other state. Geographic relevance comes from how the kit reaches you and how you access appropriate follow-up support.
The most useful buying decision starts with a clear understanding of the question the test is designed to answer.
Explore the at-home DNA Methylation Test, compare current testing options, and review the collection process before deciding whether the report fits your goals.
Informational and wellness use only. The report does not replace medical evaluation, diagnosis, or clinical laboratory testing.
Learn how the pathways work, compare tests, understand the collection process, and review common questions before ordering.
Concise answers about gene variants, MTHFR, current biomarkers, supplements and responsible result interpretation.
Commonly discussed genes include MTHFR, MTR, MTRR, COMT, AHCY, MTHFD1, SHMT1, TCN1, TCN2, FUT2 and VDR. The exact genes and variants depend on the test selected, so review the current product scope before ordering.
No. MTHFR is one part of a wider network. Genes such as MTR, MTRR, AHCY, MTHFD1, SHMT1, COMT and B12-related transport genes can add pathway context that a single MTHFR result cannot.
Not necessarily. Genetic variants are common. Their relevance depends on the specific variant, evidence supporting its interpretation, related findings and the person’s wider health context.
No. A genetic test identifies inherited variants. It does not directly measure current methylation activity or prove that a pathway is functioning poorly at the time of testing.
No. Genetic findings may provide inherited context, but they cannot confirm a current folate, vitamin B12, vitamin D, iron, zinc, or other nutrient level. Current status requires appropriate clinical assessment and laboratory testing.
A wellness report may offer general nutrition and lifestyle context, but it should not be used alone to select high-dose supplements or change medication. Discuss significant decisions with a qualified healthcare professional.
Your inherited variants do not change because you move to another city or state. Location affects delivery, sample-return transit, support access and availability of local clinical follow-up—not the DNA sequence inherited at birth.
Use the gene library to research a specific result, or review the full testing process and available products before placing an order.
